Structure and function of GPCRs / Guillaume Lebon, editor ; with contributions by F. Acher [and 33 others].
Lebon, Guillaume, editor.; Acher, F., author.
2019
QP552.G16
Available Online

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Title Structure and function of GPCRs / Guillaume Lebon, editor ; with contributions by F. Acher [and 33 others].
ISBN 9783030245917
3030245918
DOI https://doi.org/10.1007/978-3-030-24
Published Cham, Switzerland : Springer, [2019]
Language English
Description 1 online resource (299 pages).
Item Number 10.1007/978-3-030-24
Call Number QP552.G16
Dewey Decimal Classification 572.6
Summary This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Lebon, Guillaume, editor.
Acher, F., author.
Series Topics in medicinal chemistry (Springer (Firm)) ; v. 30.
Available in Other Form Structure and Function of GPCRs
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