Principles of cancer treatment and anticancer drug development / by Wolfgang Link.
2019
RC271.C5
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Details
Title
Principles of cancer treatment and anticancer drug development / by Wolfgang Link.
ISBN
9783030187224 (electronic book)
3030187225 (electronic book)
9783030187217
3030187225 (electronic book)
9783030187217
Published
Cham, Switzerland : Springer, [2019]
Language
English
Description
1 online resource (xiv, 145 pages) : illustrations.
Item Number
10.1007/978-3-030-18722-4 doi
10.1007/978-3-030-18
10.1007/978-3-030-18
Call Number
RC271.C5
Dewey Decimal Classification
616.994061
Summary
This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed September 24, 2019).
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Table of Contents
Preface
Acknowledgements
Contents
Abbreviations
Introduction
Cancer Therapy
Cancer drug resistance
Drug Discovery and Development
Economic and social implications of modern drug discovery. Index.
Acknowledgements
Contents
Abbreviations
Introduction
Cancer Therapy
Cancer drug resistance
Drug Discovery and Development
Economic and social implications of modern drug discovery. Index.