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Title
Tumor microenvironment / Peter P. Lee, Francesco M. Marincola, editors.
ISBN
9783030388621 (electronic book)
303038862X (electronic book)
3030388611
9783030388614
Published
Cham : Springer, [2020]
Copyright
©2020
Language
English
Description
1 online resource.
Item Number
10.1007/978-3-030-38862-1 doi
Call Number
RC268.3
Dewey Decimal Classification
616.99/4079
Summary
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed April 9, 2020).
Series
Cancer treatment and research ; v. 180.
Available in Other Form
Print version: 9783030388614
Preface
Part I: Imaging of tumor microenvironment, In vivo Imaging
New technologies to image tumors
Part II: Immune landscapes and their biology, Systemic correlates of the tumor microenvironment
Adaptive immunity and the tumor microenvironment
The biology of immune active cancers and their regulatory mechanisms
The biology of immune excluded cancers
Immunoscore
Part III: The tumor microenvironment and therapy, The Immune Landscape in Women Cancers
Translational biomarkers, combination therapies and their relationship with immune landscapes
Effects of radiation on the tumor microenvironment
Challenges of CAR T cell therapy for solid tumors.
