Histone mutations and cancer / Dong Fang, Junhong Han, editors.
Fang, Dong (Geneticist), editor.; Han, Junhong (Geneticist), editor.
2021
QP552.H5
Available Online

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Title Histone mutations and cancer / Dong Fang, Junhong Han, editors.
ISBN 9789811581045 electronic book
9811581045 electronic book
9789811581038 hardcover
9811581037 hardcover
DOI https://doi.org/10.1007/978-981-15-8104-5
Published Singapore : Springer, [2021]
Copyright ©2021
Language English
Description 1 online resource (vii, 96 pages) : illustrations (some color).
Item Number 10.1007/978-981-15-8104-5 doi
Call Number QP552.H5
Dewey Decimal Classification 572/.66
Summary "This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners"--Publisher's description.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Digital File Characteristics text file
PDF
Source of Description Description based on online resource; title from electronic title page (ProQuest Ebook Central, viewed on June 17, 2021).
Added Author Fang, Dong (Geneticist), editor.
Han, Junhong (Geneticist), editor.
Series Advances in experimental medicine and biology ; v. 1283. 0065-2598
Available in Other Form Histone mutations and cancer.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Overview of histone modification
The histone H3 family and its deposition pathways
Histone H3K27M mutation in brain tumors
Histone Mutations and Bone Cancers
Histone H3G34 mutation in brain and bone tumors
Epigenetic-targeted treatments for H3K27M-mutant midline gliomas
Histone lysine to methionine mutation as anti-cancer drug target.

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