SARS-CoV-2 spike protein convergent evolution : impact of virus variants on efficacy of COVID-19 therapeutics and vaccines / Daniele Focosi.
Focosi, Daniele, 1980-
2021
RA644.C67
Available Online

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Title SARS-CoV-2 spike protein convergent evolution : impact of virus variants on efficacy of COVID-19 therapeutics and vaccines / Daniele Focosi.
Author Focosi, Daniele, 1980-
ISBN 9783030873240 (electronic bk.)
3030873242 (electronic bk.)
9783030873233
3030873234
DOI https://doi.org/10.1007/978-3-030-87324-0
Publication Details Cham : Springer, 2021.
Language English
Description 1 online resource (140 pages)
Item Number 10.1007/978-3-030-87324-0 doi
Call Number RA644.C67
Dewey Decimal Classification 614.5/92414
Summary This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (Library Ideas, viewed October 22, 2021).
Series SpringerBriefs in microbiology.
Available in Other Form SARS-CoV-2 Spike Protein Convergent Evolution.
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Record Appears in Online Resources > Ebooks
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Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics
Chapter 2. SARS-CoV-2 variants
Chapter 3. Conclusion.

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