Brain organoids in research and therapy : fundamental ethical and legal aspects / Hans-Georg Dederer, David Hamburger, editors.
Dederer, Hans-Georg, editor.; Hamburger, David (Legal researcher), editor.
2022
QP376
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Title
Brain organoids in research and therapy : fundamental ethical and legal aspects / Hans-Georg Dederer, David Hamburger, editors.
ISBN
9783030976415 (electronic bk.)
3030976416 (electronic bk.)
9783030976408
3030976408
DOI
https://doi.org/10.1007/978-3-030-97641-5
Published
Cham : Springer, [2022]
Copyright
©2022
Language
English
Description
1 online resource : illustrations (chiefly color).
Item Number
10.1007/978-3-030-97641-5 doi
Call Number
QP376
Dewey Decimal Classification
616.02/774
Summary
This volume elucidates the pivotal ethical and legal issues arising from the use of brain organoids for research, therapeutic and enhancement purposes. The function of the human brain is still a mystery. Until recently, only post-mortem tissue was available for a structural examination of the brain. Consequently, the examination results could only reflect the state at the end of life. However, in order to better understand the development and function of the human brain, dynamic and functional investigations of different human brain cells are necessary. This is where brain organoids, artificially grown in vitro miniature brains, provide the opportunity for more flexible research scenarios. At the same time, however, the use of brain organoids in research and therapy raises the question of how these new entities are to be treated from an ethical and legal point of view. Against this background, this volume aims at clarifying the normative implications of the use of brain organoids in research and therapy. The ethical reflections on the status of brain organoids, informed consent, human-to-animal chimeras and neuro-enhancement are mirrored by corresponding legal analyses. The ethical and legal assessments are preceded by an introduction to the scientific and medical background of the brain organoid technology. A final chapter will be devoted to the issue of whether international harmonization of normative standards for brain organoid research and therapy is feasible and advisable.
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Description based on print version record.
Added Author
Dederer, Hans-Georg, editor.
Hamburger, David (Legal researcher), editor.
Series
Advances in neuroethics.
Available in Other Form
Brain organoids in research and therapy.
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Chapter 1) Introductory Remarks
Part I) Scientific Background
Chapter 2) Development of Brain Organoids on the Basis of Genome-Edited iPSC-Derived Brain Cells
Chapter 3) Cell-Based Therapy and Genome Editing in Parkinson's Disease: Quo Vadis
Part II) The Status Debate
Chapter 4) Human Cerebral Organoids: Evolving Entities and Their Moral Status
Chapter 5). Legal perspective: What is, or Should Be, the Legal Status of Brain Organoids?
Part III) The Informed Consent Challenge
Chapter 6) Ethical Perspective: Ethics Considerations Regarding Donors and Patients Consent
Chapter 7) The Legal Perspective: The Legal Requirements forand Limits tothe Donors and the Patients Consent
Part IV) The Chimera Issue
Chapter 8) Moral Permissibility of Transplantation of Human Brain Organoids into Animals
Chapter 9) Transplantation of Human Brain Organoids into Animals - The Legal Issues
Part V) The Enhancement Conundrum
Chapter 10) Building a Better Beast: Enhancing the Minds of Animals
Chapter 11) Legal Arguments in Favour of and Against Neuroenhancement by Means of Brain Organoids
Part VI) The Harmonization Problem
Chapter 12) Legal Perspective: A Global Harmonisation of Legal Standards for Brain Organoid Research and Therapy?. .

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