PI3K and AKT isoforms in immunity : mechanisms and therapeutic opportunities / Margarita Dominguez-Villar, editor.
Dominguez-Villar, Margarita, editor.
2022
QR185.6
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Title
PI3K and AKT isoforms in immunity : mechanisms and therapeutic opportunities / Margarita Dominguez-Villar, editor.
ISBN
9783031065668 (electronic bk.)
3031065662 (electronic bk.)
9783031065651
3031065654
DOI
https://doi.org/10.1007/978-3-031-06566-8
Published
Cham : Springer, 2022.
Language
English
Description
1 online resource : illustrations (black and white, and color).
Item Number
10.1007/978-3-031-06566-8 doi
Call Number
QR185.6
Dewey Decimal Classification
571.9/6
Summary
This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the bodys own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
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Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Dominguez-Villar, Margarita, editor.
Series
Current topics in microbiology and immunology ; 436.
Available in Other Form
PI3K and AKT isoforms in immunity.
Linked Resources
Online Access
Record Appears in
Online Resources > Ebooks
All Resources
Class I PI3K biology
Class II PI3K biology
Class III PI3K biology
PTEN in immunity
PHLPP Signaling in Immune Cells
PHLPP Signaling in Immune Cells
PI3K isoforms in cell signalling and innate immune cell responses
AKT isoforms in macrophage activation, polarization and survival
Control of CD4+ T cell Differentiation and Function by PI3K isoforms.
PI3K isoforms in CD8+ T cell development and function
PI3K isoforms in B cells
PI3K isoform signalling in platelets
PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection
PI3K and AKT at the Interface of Signaling and Metabolism
The Role of PI3K Isoforms in Autoimmune Disease
AKT Isoforms in the Immune Response in Cancer
PI3K isoform immunotherapy for solid tumours
PI3K targeting in non-solid cancer
AKT isoforms as a target in cancer and immunotherapy
Developing PI3K Inhibitors for Respiratory Diseases.

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