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Table of Contents
Intro
Preface
Postscript: In Memoriam
Contents
Chapter 1: Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates
1 Introduction
2 Monosaccharides: Building Blocks of Glycans
3 Formation of Oligosaccharides
4 Classification of Glycans
5 Structural Features of N-Glycans
6 Structural Features of O-Glycans
7 Biosynthesis of N- and O-Glycans
8 Glycosphingolipids
9 Structural Features of the Glycan Moieties of Glycosphingolipids
10 Synthesis and Functions of the Glycan Moieties of Glycolipids
11 Glycosylphosphatidylinositol Anchors: A Special Group of Glycolipids
12 Glycosaminoglycans and Proteoglycans
13 Glycan-Protein Interactions
14 Glycans of Cell Surface Glycoconjugates Perform a Variety of Functions
15 Summary
References
Chapter 2: Cells of the Central Nervous System: An Overview of Their Structure and Function
1 Introduction
2 Neurons
2.1 Neuronal Cell Body
2.2 Cytoskeleton
2.3 Dendrites
2.4 Axon
2.5 Synapse
3 Supporting Cells
3.1 Astrocytes
3.2 Oligodendrocytes
3.3 Microglia
3.4 NG2 Cells (Polydendrocytes)
3.5 Ependymal Cells
4 Extracellular Matrix
5 Concluding Remarks
References
Chapter 3: Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins
1 Introduction
2 N-glycans Are First Born on a Lipid and Then Transferred "En Bloc" onto the Nascent N-glycoprotein in the ER
3 Trimming, Reglycosylation, and Remodeling: There Are Many Ways of N-glycoprotein Processing in the ER and Golgi
4 The Essential Toolbox of a Glycobiologist: A Brief History of the Discovery of N-glycoprotein Biosynthesis Inhibitors and Their Impact on Our Understanding of N-glycan Processing
5 Sweetening the Bond or Sugar-Coating Bad News: Recent Advances in the Role of N-glycans for Virus Infections and Immune Responses
6 Sweet Encounters of Glycoproteins and Glycolipids: N-glycans Affect the Subcellular Distribution and Complex Formation of Enzymes in Glycolipid Biosynthesis
7 Conclusions and Epilogue: The Tale of the Tail That Wags the Dog
References
Chapter 4: Synthesis of O-Linked Glycoconjugates in the Nervous System
1 Introduction
2 Biosynthesis of O-Linked Proteins
2.1 O-GalNAcylation
2.2 O-Mannosylation
2.3 O-GlcNAcylation
2.4 O-Xylosylation
2.5 O-Fucosylation
2.6 O-Glucosylation
3 Biosynthesis of O-Linked Lipids
3.1 Glucosylceramide and Glycosphingolipids
3.2 Galactosylceramide and Glycosphingolipids
3.3 GlcCer and GM3 Synthase Deficiency in Human and Mouse
3.4 Other O-Linked Lipids - New Glucose-Related Lipids
4 Conclusions
References
Chapter 5: Chemistry and Function of Glycosaminoglycans in the Nervous System
1 Introduction
2 Glycosaminoglycan Structure and Chemistry
2.1 Chondroitin Sulfate (CS)
2.1.1 Structure and Chemistry
2.1.2 Synthesis and Modification of CS Chains
Preface
Postscript: In Memoriam
Contents
Chapter 1: Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates
1 Introduction
2 Monosaccharides: Building Blocks of Glycans
3 Formation of Oligosaccharides
4 Classification of Glycans
5 Structural Features of N-Glycans
6 Structural Features of O-Glycans
7 Biosynthesis of N- and O-Glycans
8 Glycosphingolipids
9 Structural Features of the Glycan Moieties of Glycosphingolipids
10 Synthesis and Functions of the Glycan Moieties of Glycolipids
11 Glycosylphosphatidylinositol Anchors: A Special Group of Glycolipids
12 Glycosaminoglycans and Proteoglycans
13 Glycan-Protein Interactions
14 Glycans of Cell Surface Glycoconjugates Perform a Variety of Functions
15 Summary
References
Chapter 2: Cells of the Central Nervous System: An Overview of Their Structure and Function
1 Introduction
2 Neurons
2.1 Neuronal Cell Body
2.2 Cytoskeleton
2.3 Dendrites
2.4 Axon
2.5 Synapse
3 Supporting Cells
3.1 Astrocytes
3.2 Oligodendrocytes
3.3 Microglia
3.4 NG2 Cells (Polydendrocytes)
3.5 Ependymal Cells
4 Extracellular Matrix
5 Concluding Remarks
References
Chapter 3: Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins
1 Introduction
2 N-glycans Are First Born on a Lipid and Then Transferred "En Bloc" onto the Nascent N-glycoprotein in the ER
3 Trimming, Reglycosylation, and Remodeling: There Are Many Ways of N-glycoprotein Processing in the ER and Golgi
4 The Essential Toolbox of a Glycobiologist: A Brief History of the Discovery of N-glycoprotein Biosynthesis Inhibitors and Their Impact on Our Understanding of N-glycan Processing
5 Sweetening the Bond or Sugar-Coating Bad News: Recent Advances in the Role of N-glycans for Virus Infections and Immune Responses
6 Sweet Encounters of Glycoproteins and Glycolipids: N-glycans Affect the Subcellular Distribution and Complex Formation of Enzymes in Glycolipid Biosynthesis
7 Conclusions and Epilogue: The Tale of the Tail That Wags the Dog
References
Chapter 4: Synthesis of O-Linked Glycoconjugates in the Nervous System
1 Introduction
2 Biosynthesis of O-Linked Proteins
2.1 O-GalNAcylation
2.2 O-Mannosylation
2.3 O-GlcNAcylation
2.4 O-Xylosylation
2.5 O-Fucosylation
2.6 O-Glucosylation
3 Biosynthesis of O-Linked Lipids
3.1 Glucosylceramide and Glycosphingolipids
3.2 Galactosylceramide and Glycosphingolipids
3.3 GlcCer and GM3 Synthase Deficiency in Human and Mouse
3.4 Other O-Linked Lipids - New Glucose-Related Lipids
4 Conclusions
References
Chapter 5: Chemistry and Function of Glycosaminoglycans in the Nervous System
1 Introduction
2 Glycosaminoglycan Structure and Chemistry
2.1 Chondroitin Sulfate (CS)
2.1.1 Structure and Chemistry
2.1.2 Synthesis and Modification of CS Chains