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Abstract
Cell signaling is essential for individual cells to execute various tasks and respond to changes in their
environment. It is carried out via diffusing molecules, whose transport is often aided by directional advection.
How diffusion and advection together impact the accuracy of information transmission during signaling remains
poorly understood. Here, we study this problem using a simplified model of signal transport in the presence and
absence of crowding. Mutual information, our measure of accuracy, shows three distinct regimes characterized
by power-law decay. Surprisingly, crowding has no measurable effect on information transmission. Our results
provide several important insights into the role of transport in cell signaling.